Publications

Callegari D, Lodola A, Pala D, Rivara S, Mor M, Rizzi A, Capelli AM. Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8. J Chem Inf Model. 2017 Jan 12. doi: 10.1021/acs.jcim.6b00679. PMID: 28080056

Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Sci Rep. 2016 Aug 8;6:31046. doi: 10.1038/srep31046. PMID: 27499063

Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A. Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents. J Med Chem. 2016 Jul 14;59(13):6387-406. doi: 10.1021/acs.jmedchem.6b00609. PMID: 27309570

Bersanelli M, Minari R, Bordi P, Gnetti L, Bozzetti C, Squadrilli A, Lagrasta CA, Bottarelli L, Osipova G, Capelletto E, Mor M, Tiseo M. L718Q Mutation as New Mechanism of Acquired Resistance to AZD9291 in EGFR-Mutated NSCLC.J Thorac Oncol. 2016 Oct;11(10):e121-3. doi: 10.1016/j.jtho.2016.05.019. PMID: 27257132

Russo S, Callegari D, Incerti M, Pala D, Giorgio C, Brunetti J, Bracci L, Vicini P, Barocelli E, Capoferri L, Rivara S, Tognolini M, Mor M, Lodola A. Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return. Chemistry. 2016 Jun 6;22(24):8048-52. doi: 10.1002/chem.201600993. PMID: 27139720

Castelli R, Giacomini A, Anselmi M, Bozza N, Vacondio F, Rivara S, Matarazzo S, Presta M, Mor M, Ronca R. Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors. J Med Chem. 2016 May 26;59(10):4651-63. doi: 10.1021/acs.jmedchem.5b02021. PMID: 27138345

Tarozzi A, Marchetti C, Nicolini B, D'Amico M, Ticchi N, Pruccoli L, Tumiatti V, Simoni E, Lodola A, Mor M, Milelli A, Minarini A. Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate. Eur J Med Chem. 2016 Jul 19;117:283-91. doi: 10.1016/j.ejmech.2016.04.002. PMID: 27135370

Carnevali L, Rivara S, Nalivaiko E, Thayer JF, Vacondio F, Mor M, Sgoifo A. Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity? Neurosci Biobehav Rev. 2016 Apr 27. pii: S0149-7634(16)30031-8. doi: 10.1016/j.neubiorev.2016.04.013.  PMID: 27131970

Pala D, Rivara S, Mor M, Milazzo FM, Roscilli G, Pavoni E, Giannini G. Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase. Glycobiology. 2016 Jun;26(6):640-54. doi: 10.1093/glycob/cww003. PMID: 26762172

Mugnaini C, Brizzi A, Ligresti A, Allarà M, Lamponi S, Vacondio F, Silva C, Mor M, Di Marzo V, Corelli F. Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility.J Med Chem. 2016 Feb 11;59(3):1052-67. doi: 10.1021/acs.jmedchem.5b01559. PMID: 26756097

Giorgio C, Russo S, Incerti M, Bugatti A, Vacondio F, Barocelli E, Mor M, Pala D, Hassan-Mohamed I, Gioiello A, Rusnati M, Lodola A, Tognolini M. Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis. Biochem Pharmacol. 2016 Jan 1;99:18-30. doi: 10.1016/j.bcp.2015.10.006. PMID: 26462575

Castelli R, Tognolini M, Vacondio F, Incerti M, Pala D, Callegari D, Bertoni S, Giorgio C, Hassan-Mohamed I, Zanotti I, Bugatti A, Rusnati M, Festuccia C, Rivara S, Barocelli E, Mor M, Lodola A. Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system. Eur J Med Chem. 2015 Aug 29;103:312-324. doi: 10.1016/j.ejmech.2015.08.048 PMID: 26363867

Spadoni G, Bedini A, Lucarini S, Mari M, Caignard DH, Boutin JA, Delagrange P, Lucini V, Scaglione F, Lodola A, Zanardi F, Pala D, Mor M, Rivara S. Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines. J Med Chem. 2015 Sep 14. [Epub ahead of print] PMID: 26334942

Ronca R, Giacomini A, Di Salle E, Coltrini D, Pagano K, Ragona L, Matarazzo S, Rezzola S, Maiolo D, Torrella R, Moroni E, Mazzieri R, Escobar G, Mor M, Colombo G, Presta M. Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. Cancer Cell.2015 Aug 10;28(2):225-39. doi: 10.1016/j.ccell.2015.07.002. PMID: 26267536

Scalvini L, Piomelli D, Mor M. Monoglyceride lipase: Structure and inhibitors. Chem Phys Lipids. 2015 Jul 26. pii: S0009-3084(15)30016-5. doi: 10.1016/j.chemphyslip.2015.07.011. [Epub ahead of print] PMID: 26216043

Vacondio F, Bassi M, Silva C, Castelli R, Carmi C, Scalvini L, Lodola A, Vivo V, Flammini L, Barocelli E, Mor M, Rivara S. Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats. PLoS One. 2015 Jun 8;10(6):e0128699. doi: 10.1371/journal.pone.0128699. eCollection 2015. PMID: 26053855

Dotsey EY, Jung KM, Basit A, Wei D, Daglian J, Vacondio F, Armirotti A, Mor M, Piomelli D. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chem Biol. 2015 May 21;22(5):619-28. doi: 10.1016/j.chembiol.2015.04.013. PMID: 26000748

Spadoni G, Bedini A, Lucarini S, Mor M, Rivara S. Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy. Expert Opin Drug Metab Toxicol. 2015 Jul;11(7):1145-56. doi: 10.1517/17425255.2015.1045487. Epub 2015 May 8. PMID: 25956235

Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. doi: 10.1021/acschembio.5b00114. Epub 2015 Apr 15.

Curti C, Sartori A, Battistini L, Brindani N, Rassu G, Pelosi G, Lodola A, Mor M, Casiraghi G, Zanardi F. Pushing the boundaries of vinylogous reactivity: catalytic enantioselective mukaiyama aldol reactions of highly unsaturated 2-silyloxyindoles. Chemistry. 2015 Apr 20;21(17):6433-42. doi: 10.1002/chem.201500083. Epub 2015 Mar 3. PMID: 25735832

Santucci M, Vignudelli T, Ferrari S, Mor M, Scalvini L, Bolognesi ML, Uliassi E, Costi MP. The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment. J Med Chem. 2015 Jun 25;58(12):4857-73. doi: 10.1021/jm501615v. Epub 2015 Mar 11. PMID: 25719868

Capoferri L, Lodola A, Rivara S, Mor M. Quantum mechanics/molecular mechanics modeling of covalent addition between EGFR-cysteine 797 and N-(4-anilinoquinazolin-6-yl) acrylamide. J Chem Inf Model. 2015 Mar 23;55(3):589-99. doi: 10.1021/ci500720e. Epub 2015 Feb 17. PMID: 25658136

Lodola A, Rivara S, Mor M. Insights in the mechanism of action and inhibition of N-acylethanolamine acid amidase by means of computational methods. Adv Protein Chem Struct Biol. 2014;96:219-34. doi: 10.1016/bs.apcsb.2014.06.007. Epub 2014 Aug 24. PMID: 25443959

Giedroyć-Piasecka W, Dyguda-Kazimierowicz E, Beker W, Mor M, Lodola A, Sokalski WA. Physical Nature of Fatty Acid Amide Hydrolase Interactions with Its Inhibitors: Testing a Simple Nonempirical Scoring Model. J Phys Chem B. 2014 Dec 10. [Epub ahead of print] PMID: 25420234

Pala D, Castelli R, Incerti M, Russo S, Tognolini M, Giorgio C, Hassan-Mohamed I, Zanotti I, Vacondio F, Rivara S, Mor M, Lodola A. Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction. J Chem Inf Model. 2014 Oct 27;54(10):2621-6. doi: 10.1021/ci5004619. Epub 2014 Oct 7. PMID: 25289483

Giannini G, Vesci L, Battistuzzi G, Vignola D, Milazzo FM, Guglielmi MB, Barbarino M, Santaniello M, Fantò N, Mor M, Rivara S, Pala D, Taddei M, Pisano C, Cabri W. ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors. J Med Chem. 2014 Oct 23;57(20):8358-77. doi: 10.1021/jm5008209. Epub 2014 Oct 8. PMID: 25233084

Pala D, Scalvini L, Lodola A, Mor M, Flammini L, Barocelli E, Lucini V, Scaglione F, Bartolucci S, Bedini A, Rivara S, Spadoni G. Synthesis and characterization of new bivalent agents as melatonin- and histamine H₃-ligands. Int J Mol Sci. 2014 Sep 12;15(9):16114-33. doi: 10.3390/ijms150916114. PMID: 25222552

Berteotti A, Vacondio F, Lodola A, Bassi M, Silva C, Mor M, Cavalli A. Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study. ACS Med Chem Lett. 2014 Feb 24;5(5):501-5. doi: 10.1021/ml400489b. eCollection 2014 May 8. PMID: 24900869

Fiasella A, Nuzzi A, Summa M, Armirotti A, Tarozzo G, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. 3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. ChemMedChem. 2014 Jul;9(7):1602-14. doi: 10.1002/cmdc.201300546. Epub 2014 May 14. PMID: 24828120

Damiano F, Silva C, Gregori A, Vacondio F, Mor M, Menozzi M, Di Giorgio D. Analysis of illicit dietary supplements sold in the Italian market: identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS. Sci Justice. 2014 May;54(3):228-37. doi: 10.1016/j.scijus.2014.02.009. Epub 2014 Mar 14. PMID: 24796952

Spadoni G, Bedini A, Bartolucci S, Pala D, Mor M, Riccioni T, Borsini F, Cabri W, Celona D, Marzi M, Tarzia G, Rivara S, Minetti P Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties. Eur J Med Chem. 2014 Jun 10;80:8-35. doi: 10.1016/j.ejmech.2014.04.034. Epub 2014 Apr 13. PMID: 24763360

Hassan-Mohamed I, Giorgio C, Incerti M, Russo S, Pala D, Pasquale EB, Zanotti I, Vicini P, Barocelli E, Rivara S, Mor M, Lodola A, Tognolini M. UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. Br J Pharmacol. 2014 Dec;171(23):5195-208. doi: 10.1111/bph.12669. Epub 2014 Aug 28. PMID: 24597515

Russo S, Incerti M, Tognolini M, Castelli R, Pala D, Hassan-Mohamed I, Giorgio C, De Franco F, Gioiello A, Vicini P, Barocelli E, Rivara S, Mor M, Lodola A. Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor. Molecules. 2013 Oct 21;18(10):13043-60. doi: 10.3390/molecules181013043. PMID: 24152675

Ponzano S, Bertozzi F, Mengatto L, Dionisi M, Armirotti A, Romeo E, Berteotti A, Fiorelli C, Tarozzo G, Reggiani A, Duranti A, Tarzia G, Mor M, Cavalli A, Piomelli D, Bandiera T. Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. J Med Chem. 2013 Sep 12;56(17):6917-34. doi: 10.1021/jm400739u. Epub 2013 Aug 30. PMID: 23991897

Vacondio F, Carmi C, Galvani E, Bassi M, Silva C, Lodola A, Rivara S, Cavazzoni A, Alfieri RR, Petronini PG, Mor M. Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5290-4. doi: 10.1016/j.bmcl.2013.08.008. Epub 2013 Aug 11. PMID: 23988354

Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. J Med Chem. 2013 Jul 25;56(14):5917-30. doi: 10.1021/jm4007017. Epub 2013 Jul 3. PMID: 23822179

Rossi A, Buttini F, Colombo P, Mor M, Pala D, Bortolotti F, Colombo G. Complex product composition generates risks for generic substitution also with dosage forms for intravenous administration. Int J Pharm. 2013 Jul 15;451(1-2):50-6. doi: 10.1016/j.ijpharm.2013.04.064. Epub 2013 Apr 27. PMID: 23628401

Chudyk EI, Dyguda-Kazimierowicz E, Langner KM, Sokalski WA, Lodola A, Mor M, Sirirak J, Mulholland AJ. Nonempirical energetic analysis of reactivity and covalent inhibition of fatty acid amide hydrolase. J Phys Chem B. 2013 Jun 6;117(22):6656-66. doi: 10.1021/jp401834v. Epub 2013 May 28. PubMed PMID: 23654226.

Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem. 2013 May 9;56(9):3518-30. doi: 10.1021/jm301879g. PubMed PMID: 23614460.

Pala D, Beuming T, Sherman W, Lodola A, Rivara S, Mor M. Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement. J Chem Inf Model. 2013 Apr 22;53(4):821-35. doi: 10.1021/ci4000147. Epub 2013 Apr 9. PubMed PMID: 23541165.  

Incerti M, Tognolini M, Russo S, Pala D, Giorgio C, Hassan-Mohamed I, Noberini R, Pasquale EB, Vicini P, Piersanti S, Rivara S, Barocelli E, Mor M, Lodola A. Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. doi: 10.1021/jm301890k. Epub 2013 Mar 22. PubMed PMID: 23489211.

Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors. J Med Chem. 2013 Mar 28;56(6):2500-12. doi: 10.1021/jm301867x. PMID: 23425199; PubMed Central PMCID: PMC3724458.   

Sasso O, Moreno-Sanz G, Martucci C, Realini N, Dionisi M, Mengatto L, Duranti A, Tarozzo G, Tarzia G, Mor M, Bertorelli R, Reggiani A, Piomelli D. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154(3):350-60. doi: 10.1016/j.pain.2012.10.018. PubMed PMID: 23218523; PubMed Central PMCID: PMC3723234.

Rivara S, Piersanti G, Bartoccini F, Diamantini G, Pala D, Riccioni T, Stasi  MA, Cabri W, Borsini F, Mor M, Tarzia G, Minetti P. Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors. J Med Chem. 2013 Feb 14;56(3):1247-61. doi: 10.1021/jm301686s. PubMed PMID: 23281824.

Galvani E, Alfieri R, Giovannetti E, Cavazzoni A, La Monica S, Galetti M, Fumarola C, Bonelli M, Mor M, Tiseo M, Peters GJ, Petronini PG, Ardizzoni A. Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer. Curr Pharm Des. 2013;19(5):818-32. Review. PubMed PMID: 22973953.

Galvani E, Giovannetti E, Saccani F, Cavazzoni A, Leon LG, Dekker H, Alfieri  R, Carmi C, Mor M, Ardizzoni A, Petronini PG, Peters GJ. Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer. Neoplasia. 2013 Jan;15(1):61-72. PubMed PMID: 23359111; PubMed Central PMCID: PMC3556939.   

Ochoa-Sanchez R, Rainer Q, Comai S, Spadoni G, Bedini A, Rivara S, Fraschini  F, Mor M, Tarzia G, Gobbi G. Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Dec 3;39(2):318-25. doi: 10.1016/j.pnpbp.2012.07.003. PubMed PMID: 22789661.

Carmi C, Mor M, Petronini PG, Alfieri RR. Clinical perspectives for irreversible tyrosine kinase inhibitors in cancer. Biochem Pharmacol. 2012 Dec 1;84(11):1388-99. doi: 10.1016/j.bcp.2012.07.031. Review. PubMed PMID: 22885287.

Bartoccini F, Piersanti G, Mor M, Tarzia G, Minetti P, Cabri W. Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions. Org Biomol Chem. 2012 Nov 28;10(44):8860-7. doi: 10.1039/c2ob26516h. PubMed PMID: 23047760.

Rivara S, Pala D, Lodola A, Mor M, Lucini V, Dugnani S, Scaglione F, Bedini A, Lucarini S, Tarzia G, Spadoni G. MT(1) Selective Melatonin Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Dynamics Investigation of N-{[(3-O-Substituted)anilino]alkyl}amides. ChemMedChem. 2012 Aug 27. doi: 10.1002/cmdc.201200303. [Epub ahead of print] PubMed PMID: 22927210.

Vacondio F, Silva C, Flammini L, Ballabeni V, Barocelli E, Mor M. Brain pharmacokinetics of non-imidazole biphenyl H3 receptor antagonists: a liquid chromatography/electrospray-mass spectrometry and ex vivo binding study in rats.  Chem Biodivers. 2012 Jul;9(7):1231-9. doi: 10.1002/cbdv.201100242. PubMed PMID: 22782872.

Tognolini M, Incerti M, Hassan-Mohamed I, Giorgio C, Russo S, Bruni R, Lelli  B, Bracci L, Noberini R, Pasquale EB, Barocelli E, Vicini P, Mor M, Lodola A. Structure-activity relationships and mechanism of action of Eph-ephrin antagonists: interaction of cholanic acid with the EphA2 receptor. ChemMedChem. 2012 Jun;7(6):1071-83. doi: 10.1002/cmdc.201200102. PubMed PMID: 22529030; PubMed Central PMCID: PMC3677030.

Duranti A, Tontini A, Antonietti F, Vacondio F, Fioni A, Silva C, Lodola A, Rivara S, Solorzano C, Piomelli D, Tarzia G, Mor M. N-(2-oxo-3-oxetanyl)carbamic  acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. J Med Chem. 2012 May 24;55(10):4824-36. doi: 10.1021/jm300349j. PubMed PMID: 22515328.

Carmi C, Galvani E, Vacondio F, Rivara S, Lodola A, Russo S, Aiello S, Bordi  F, Costantino G, Cavazzoni A, Alfieri RR, Ardizzoni A, Petronini PG, Mor M. Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides. J Med Chem. 2012 Mar 8;55(5):2251-64. doi: 10.1021/jm201507x. PubMed PMID: 22280453.

Bordi F, Rivara S, Dallaturca E, Carmi C, Pala D, Lodola A, Vacondio F, Flammini L, Bertoni S, Ballabeni V, Barocelli E, Mor M. Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain. Eur J Med Chem. 2012 Feb;48:214-30. doi: 10.1016/j.ejmech.2011.12.019. PubMed PMID: 22222138.

Lodola A, Branduardi D, De Vivo M, Capoferri L, Mor M, Piomelli D, Cavalli A. A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. PLoS One. 2012;7(2):e32397. doi: 10.1371/journal.pone.0032397. PubMed PMID: 22389698; PubMed Central PMCID: PMC3289653.

Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in  neurons. Nat Neurosci. 2012;15(1):64-9. doi: 10.1038/nn.2986. PubMed PMID: 22101642; PubMed Central PMCID: PMC3245783.

Bedini A, Lucarini S, Spadoni G, Tarzia G, Scaglione F, Dugnani S, Pannacci M, Lucini V, Carmi C, Pala D, Rivara S, Mor M. Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives. J Med Chem. 2011 Dec 22;54(24):8362-72. doi: 10.1021/jm200790v. PubMed PMID: 22047556.

Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. J Neurosci. 2011 Dec 14;31(50):18439-52. doi: 10.1523/JNEUROSCI.2676-11.2011. PubMed PMID: 22171046.

Spadoni G, Bedini A, Rivara S, Mor M. Melatonin receptor agonists: new options for insomnia and depression treatment. CNS Neurosci Ther. 2011 Dec;17(6):733-41. doi: 10.1111/j.1755-5949.2010.00197.x. Review. PubMed PMID: 21554566.

Alfieri RR, Galetti M, Tramonti S, Andreoli R, Mozzoni P, Cavazzoni A, Bonelli M, Fumarola C, La Monica S, Galvani E, De Palma G, Mutti A, Mor M, Tiseo  M, Mari E, Ardizzoni A, Petronini PG. Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines. Mol Cancer. 2011 Nov 23;10:143. doi: 10.1186/1476-4598-10-143. PubMed PMID: 22111840; PubMed Central PMCID: PMC3281800.

Palermo G, Branduardi D, Masetti M, Lodola A, Mor M, Piomelli D, Cavalli A, De Vivo M. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. J Med Chem. 2011 Oct 13;54(19):6612-23. doi: 10.1021/jm2004283. PubMed PMID: 21830831.

Curti C, Battistini L, Sartori A, Lodola A, Mor M, Rassu G, Pelosi G, Zanardi F, Casiraghi G. Catalytic, asymmetric hypervinylogous Mukaiyama aldol reactions of extended furan-based silyl enolates. Org Lett. 2011 Sep 2;13(17):4738-41. doi: 10.1021/ol2020626. PubMed PMID: 21834551.

Vacondio F, Silva C, Lodola A, Carmi C, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Tarzia G, Mor M. Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. Eur J Med Chem. 2011 Sep;46(9):4466-73. doi: 10.1016/j.ejmech.2011.07.021. PubMed PMID: 21820769; PubMed Central PMCID: PMC3714604.

Capoferri L, Mor M, Sirirak J, Chudyk E, Mulholland AJ, Lodola A. Application of a SCC-DFTB QM/MM approach to the investigation of the catalytic mechanism of fatty acid amide hydrolase. J Mol Model. 2011 Sep;17(9):2375-83. doi: 10.1007/s00894-011-0981-z PubMed PMID: 21365225.

Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G, Mor M, Rivara S, Lucini V, Pannacci M, Scaglione F. Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem. 2011 Aug 15;19(16):4910-6. doi: 10.1016/j.bmc.2011.06.063. PubMed PMID: 21775151.

Vacondio F, Silva C, Morini G, Bordi F, Flammini L, Barocelli E, Mor M. Liquid chromatography-mass spectrometric method for determination of the non-imidazole H3-receptor antagonist UPR1056 in rat plasma. J Sep Sci. 2011 Jul;34(14):1656-63. doi: 10.1002/jssc.201000845. PubMed PMID: 21648077.

Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chem Commun (Camb). 2011 Mar 7;47(9):2517-9. doi: 10.1039/c0cc04937a. PubMed PMID: 21240393.

Lodola A, Rivara S, Mor M. Application of computational methods to the design of fatty acid amide hydrolase (FAAH) inhibitors based on a carbamic template structure. Adv Protein Chem Struct Biol. 2011;85:1-26. doi: 10.1016/B978-0-12-386485-7.00001-6. Review. PubMed PMID: 21920320.
 

Vacondio F, Silva C, Mor M, Testa B. Qualitative structure-metabolism relationships in the hydrolysis of carbamates. Drug Metab Rev. 2010 Nov;42(4):551-89. doi: 10.3109/03602531003745960. Review. PubMed PMID: 20441444.

Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M,  Tarzia G, Piomelli D. Anandamide suppresses pain initiation through a peripheral  endocannabinoid mechanism. Nat Neurosci. 2010 Oct;13(10):1265-70. doi: 10.1038/nn.2632. PubMed PMID: 20852626; PubMed Central PMCID: PMC3260554.

Solorzano C, Antonietti F, Duranti A, Tontini A, Rivara S, Lodola A, Vacondio F, Tarzia G, Piomelli D, Mor M. Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem. 2010 Aug 12;53(15):5770-81. doi: 10.1021/jm100582w. PubMed PMID: 20604568; PubMed Central PMCID: PMC2932887.

Mor M, Rivara S, Pala D, Bedini A, Spadoni G, Tarzia G. Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists. Expert Opin Ther Pat. 2010 Aug;20(8):1059-77. doi: 10.1517/13543776.2010.496455. Review. PubMed PMID: 20533893.

Galetti M, Alfieri RR, Cavazzoni A, La Monica S, Bonelli M, Fumarola C, Mozzoni P, De Palma G, Andreoli R, Mutti A, Mor M, Tiseo M, Ardizzoni A, Petronini PG. Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines. Biochem Pharmacol. 2010 Jul 15;80(2):179-87. doi: 10.1016/j.bcp.2010.03.033. PubMed PMID: 20363215.

Carmi C, Cavazzoni A, Vezzosi S, Bordi F, Vacondio F, Silva C, Rivara S, Lodola A, Alfieri RR, La Monica S, Galetti M, Ardizzoni A, Petronini PG, Mor M. Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion. J Med Chem. 2010 Mar 11;53(5):2038-50. doi: 10.1021/jm901558p. PubMed PMID: 20151670.

Lodola A, Sirirak J, Fey N, Rivara S, Mor, Mulholland AJ. Structural Fluctuations in Enzyme-Catalyzed Reactions: Determinants of Reactivity in Fatty Acid Amide Hydrolase from Multivariate Statistical Analysis of Quantum Mechanics/Molecular Mechanics Paths. J. Chem Theor Comput 2010, 6, 2948-2960.

Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo  R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20966-71. doi: 10.1073/pnas.0907417106. PubMed PMID: 19926854; PubMed Central PMCID: PMC2791595.

King AR, Lodola A, Carmi C, Fu J, Mor M, Piomelli D. A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors. Br J Pharmacol. 2009 Jul;157(6):974-83. doi: 10.1111/j.1476-5381.2009.00276.x.

King AR, Dotsey EY, Lodola A, Jung KM, Ghomian A, Qiu Y, Fu J, Mor M, Piomelli D. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30;16(10):1045-52. doi: 10.1016/j.chembiol.2009.09.012. PubMed PMID: 19875078; PubMed Central PMCID: PMC3034734.

Rivara S, Vacondio F, Fioni A, Silva C, Carmi C, Mor M, Lucini V, Pannacci M, Caronno A, Scaglione F, Gobbi G, Spadoni G, Bedini A, Orlando P, Lucarini S, Tarzia G. N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. ChemMedChem. 2009 Oct;4(10):1746-55. doi: 10.1002/cmdc.200900240. PubMed PMID: 19728346.  

Clapper JR, Vacondio F, King AR, Duranti A, Tontini A, Silva C, Sanchini S, Tarzia G, Mor M, Piomelli D. A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo. ChemMedChem. 2009 Sep;4(9):1505-13. doi: 10.1002/cmdc.200900210. PubMed PMID: 19637155; PubMed Central PMCID: PMC3016090.

Vacondio F, Silva C, Lodola A, Fioni A, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Mor M, Tarzia G. Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. ChemMedChem. 2009 Sep;4(9):1495-504. doi: 10.1002/cmdc.200900120. PubMed PMID: 19554599; PubMed Central PMCID: PMC3517974.

Zuliani V, Carmi C, Rivara M, Fantini M, Lodola A, Vacondio F, Bordi F, Plazzi PV, Cavazzoni A, Galetti M, Alfieri RR, Petronini PG, Mor M. 5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line. Eur J Med Chem. 2009 Sep;44(9):3471-9. doi: 10.1016/j.ejmech.2009.01.035. PubMed PMID: 19268405.   

Rivara M, Zuliani V, Fantini M, Dallaturca E, Mor M. Chiral NMR discrimination of the diastereoisomeric salts of the H3-antagonist 2-[3-(1H-imidazol-4-ylmethyl)piperidin-1-yl]-1H-benzimidazole. Magn Reson Chem. 2009 Jun;47(6):515-8. doi: 10.1002/mrc.2418. PubMed PMID: 19288549.

Lodola A, Mor M, Sirirak J, Mulholland AJ. Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling. Biochem Soc Trans. 2009 Apr;37(Pt 2):363-7. doi: 10.1042/BST0370363. Review. PubMed PMID: 19290863.

Valitutti G, Duranti A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with  biological activity. J Mass Spectrom. 2009 Apr;44(4):561-5. doi: 10.1002/jms.1524. Erratum in: J Mass Spectrom. 2011 Aug;46(8):847. PubMed PMID: 19034887.

Lo Verme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C,  Tarzia G, Piomelli D. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett. 2009 Feb 1;19(3):639-43. doi: 10.1016/j.bmcl.2008.12.059. PubMed PMID: 19128970; PubMed Central PMCID: PMC3690177.

Mor M, Lodola A. Pharmacological tools in endocannabinoid neurobiology. Curr Top Behav Neurosci. 2009;1:87-110. doi: 10.1007/978-3-540-88955-7_4. PubMed PMID: 21104381.
 

Morini G, Comini M, Rivara M, Rivara S, Bordi F, Plazzi PV, Flammini L, Saccani F, Bertoni S, Ballabeni V, Barocelli E, Mor M. Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorg Med Chem. 2008 Dec 1;16(23):9911-24. doi: 10.1016/j.bmc.2008.10.029. PubMed PMID:  18976927.

Mor M, Lodola A, Rivara S, Vacondio F, Duranti A, Tontini A, Sanchini S, Piersanti G, Clapper JR, King AR, Tarzia G, Piomelli D. Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. J Med Chem. 2008 Jun 26;51(12):3487-98. doi: 10.1021/jm701631z. Erratum in: J Med Chem. 2009 Jan 8;52(1):224. PubMed PMID: 18507372; PubMed Central PMCID: PMC3744893.

Cavazzoni A, Alfieri RR, Carmi C, Zuliani V, Galetti M, Fumarola C, Frazzi R, Bonelli M, Bordi F, Lodola A, Mor M, Petronini PG. Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines. Mol Cancer Ther. 2008 Feb;7(2):361-70. doi: 10.1158/1535-7163.MCT-07-0477. PubMed PMID: 18281519.

Lodola A, Mor M, Rivara S, Christov C, Tarzia G, Piomelli D, Mulholland AJ. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chem Commun (Camb). 2008 Jan 14;(2):214-6. PubMed PMID: 18092091.   

Vacondio F, Silva C, Fioni A, Mor M, Rivara M, Bordi F, Flammini L, Ballabeni V, Barocelli E. Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H3 antagonist ROS203 in rat plasma. J Pharm Biomed Anal. 2008 Jan 7;46(1):200-5. PubMed PMID: 17959330.

Rivara M, Vacondio F, Silva C, Zuliani V, Fantini M, Bordi F, Plazzi PV, Bertoni S, Ballabeni V, Flammini L, Barocelli E, Mor M. Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor. Chem Biodivers. 2008 Jan;5(1):140-52. doi: 10.1002/cbdv.200890004. PubMed PMID: 18205116.

Rivara S, Mor M, Bedini A, Spadoni G, Tarzia G. Melatonin receptor agonists:  SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68. Review. PubMed PMID: 18673165.
 

Rivara S, Lodola A, Mor M, Bedini A, Spadoni G, Lucini V, Pannacci M, Fraschini F, Scaglione F, Sanchez RO, Gobbi G, Tarzia G. N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J Med Chem. 2007 Dec 27;50(26):6618-26. PubMed PMID: 18052314.

King AR, Duranti A, Tontini A, Rivara S, Rosengarth A, Clapper JR, Astarita G, Geaga JA, Luecke H, Mor M, Tarzia G, Piomelli D. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. PubMed PMID: 18096504; PubMed Central PMCID: PMC2225625.

Spadoni G, Bedini A, Diamantini G, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Caronno A, Fraschini F. Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists. ChemMedChem. 2007 Dec;2(12):1741-9. PubMed PMID: 17907131.

Valitutti G, Duranti A, Lodola A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate  FAAH inhibitors. J Mass Spectrom. 2007 Dec;42(12):1624-7. PubMed PMID: 18085570.

Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry. 2007 Nov 15;62(10):1103-10. PubMed PMID: 17511970.   
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arzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Ann Chim. 2007 Sep;97(9):887-94. PubMed PMID: 17970304.

Russo R, Loverme J, La Rana G, Compton TR, Parrott J, Duranti A, Tontini A, Mor M, Tarzia G, Calignano A, Piomelli D. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther. 2007 Jul;322(1):236-42. PubMed PMID: 17412883.

Lodola A, Mor M, Zurek J, Tarzia G, Piomelli D, Harvey JN, Mulholland AJ. Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophys J. 2007 Jan 15;92(2):L20-2. PubMed PMID: 17098788; PubMed Central PMCID: PMC1751413.
 

Bedini A, Spadoni G, Gatti G, Lucarini S, Tarzia G, Rivara S, Lorenzi S, Lodola A, Mor M, Lucini V, Pannacci M, Scaglione F. Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands. J Med Chem. 2006 Dec 14;49(25):7393-403. PubMed PMID: 17149869.

Clapper JR, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacol Res. 2006 Nov;54(5):341-4. PubMed PMID:  16935521.

Carmi C, Cavazzoni A, Zuliani V, Lodola A, Bordi F, Plazzi PV, Alfieri RR, Petronini PG, Mor M. 5-benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4021-5. PubMed PMID: 16713265.

Morini G, Comini M, Rivara M, Rivara S, Lorenzi S, Bordi F, Mor M, Flammini L, Bertoni S, Ballabeni V, Barocelli E, Plazzi PV. Dibasic non-imidazole histamine H3 receptor antagonists with a rigid biphenyl scaffold. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4063-7. PubMed PMID: 16713264.

Astarita G, Di Giacomo B, Gaetani S, Oveisi F, Compton TR, Rivara S, Tarzia G, Mor M, Piomelli D. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther. 2006 Aug;318(2):563-70. PubMed PMID: 16702440.

Rivara S, Diamantini G, Di Giacomo B, Lamba D, Gatti G, Lucini V, Pannacci M, Mor M, Spadoni G, Tarzia G. Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling  of a constrained chiral melatonin analogue. Bioorg Med Chem. 2006 May 15;14(10):3383-91. PubMed PMID: 16431121.

Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006 Spring;12(1):21-38. Review. PubMed PMID: 16834756.

Spadoni G, Diamantini G, Bedini A, Tarzia G, Vacondio F, Silva C, Rivara M, Mor M, Plazzi PV, Zusso M, Franceschini D, Giusti P. Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity. J Pineal Res. 2006 Apr;40(3):259-69. PubMed PMID: 16499563.

Rivara M, Zuliani V, Cocconcelli G, Morini G, Comini M, Rivara S, Mor M, Bordi F, Barocelli E, Ballabeni V, Bertoni S, Plazzi PV. Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series. Bioorg Med Chem. 2006 Mar 1;14(5):1413-24. PubMed PMID: 16263297.

Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring. ChemMedChem. 2006 Jan;1(1):130-9. PubMed PMID: 16892344.
 

Mor M, Rivara S, Lodola A, Lorenzi S, Bordi F, Plazzi PV, Spadoni G, Bedini A, Duranti A, Tontini A, Tarzia G. Application of 3D-QSAR in the rational design  of receptor ligands and enzyme inhibitors. Chem Biodivers. 2005 Nov;2(11):1438-51. PubMed PMID: 17191945.
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orenzi S, Mor M, Bordi F, Rivara S, Rivara M, Morini G, Bertoni S, Ballabeni V, Barocelli E, Plazzi PV. Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists. Bioorg Med Chem. 2005 Oct 1;13(19):5647-57. PubMed PMID: 16085419.

Lodola A, Mor M, Hermann JC, Tarzia G, Piomelli D, Mulholland AJ. QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation. Chem Commun (Camb). 2005 Sep 21;(35):4399-401. PubMed PMID: 16136230.

Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat Neurosci. 2005 Sep;8(9):1139-41. Erratum in: Nat Neurosci. 2007 Jan;10(1):134. PubMed PMID: 16116451.

Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. An endocannabinoid mechanism for stress-induced analgesia. Nature. 2005 Jun 23;435(7045):1108-12. PubMed PMID: 15973410.  

Rivara S, Lorenzi S, Mor M, Plazzi PV, Spadoni G, Bedini A, Tarzia G. Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models. J Med Chem. 2005 Jun 16;48(12):4049-60. PubMed PMID: 15943478.

Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic  acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005 Apr;313(1):352-8. PubMed PMID: 15579492.

Basso E, Duranti A, Mor M, Piomelli D, Tontini A, Tarzia G, Traldi P. Tandem  mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters. J Mass Spectrom. 2004 Dec;39(12):1450-5. PubMed PMID: 15578755.

Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling  studies. J Med Chem. 2004 Oct 7;47(21):4998-5008. PubMed PMID: 15456244.

Vacondio F, Mor M, Silva C, Zuliani V, Rivara M, Rivara S, Bordi F, Plazzi PV, Magnanini F, Bertoni S, Ballabeni V, Barocelli E, Carrupt PA, Testa B. Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors. Eur J Pharm Sci. 2004 Sep;23(1):89-98. PubMed PMID: 15324926.   

Lucini V, Pannacci M, Scaglione F, Fraschini F, Rivara S, Mor M, Bordi F, Plazzi PV, Spadoni G, Bedini A, Piersanti G, Diamantini G, Tarzia G. Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity. J Med Chem. 2004 Aug 12;47(17):4202-12. PubMed PMID: 15293992.

Amari G, Armani E, Ghirardi S, Delcanale M, Civelli M, Caruso PL, Galbiati E, Lipreri M, Rivara S, Lodola A, Mor M. Synthesis, pharmacological evaluation, and  structure-activity relationships of benzopyran derivatives with potent SERM activity. Bioorg Med Chem. 2004 Jul 15;12(14):3763-82. Erratum in: Bioorg Med Chem. 2004 Sep 15;12(18):5011. PubMed PMID: 15210143.

Mor M, Silva C, Vacondio F, Plazzi PV, Bertoni S, Spadoni G, Diamantini G, Bedini A, Tarzia G, Zusso M, Franceschini D, Giusti P. Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities. J Pineal Res. 2004 Mar;36(2):95-102. PubMed PMID: 14962060.

Mor M, Bordi F, Silva C, Rivara S, Zuliani V, Vacondio F, Rivara M, Barocelli E, Bertoni S, Ballabeni V, Magnanini F, Impicciatore M, Plazzi PV. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74. PubMed PMID: 14759727.
 

Tarzia G, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Plazzi PV, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists. Bioorg Med Chem. 2003 Sep 1;11(18):3965-73. PubMed PMID: 12927857.

Silva C, Mor M, Vacondio F, Zuliani V, Vincenzo Plazzi PV. pH-partition profiles of 4-(3-oxo-1,2-benzisothiazolin-2-yl)phenyl and phenoxyalkanoic acids. Farmaco. 2003 Sep;58(9):989-93. PubMed PMID: 13679196.
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arzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, Piomelli D. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide  hydrolase inhibitors. J Med Chem. 2003 Jun 5;46(12):2352-60. PubMed PMID: 12773040.

Rivara S, Mor M, Silva C, Zuliani V, Vacondio F, Spadoni G, Bedini A, Tarzia  G, Lucini V, Pannacci M, Fraschini F, Plazzi PV. Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation. J Med Chem. 2003 Apr 10;46(8):1429-39. PubMed PMID: 12672242.

Spadoni G, Bedini A, Piersanti G, Mor M, Rivara S, Tarzia G. Strategies leading to MT2 selective melatonin receptor antagonists. Adv Exp Med Biol. 2003;527:577-85. PubMed PMID: 15206776.

Mor M, Spadoni G, Diamantini G, Bedini A, Tarzia G, Silva C, Vacondio F, Rivara M, Plazzi PV, Franceschini D, Zusso M, Giusti P. Antioxidant and cytoprotective activity of indole derivatives related to melatonin. Adv Exp Med Biol. 2003;527:567-75. PubMed PMID: 15206775.

Rivara S, Mor M, Bordi F, Silva C, Zuliani V, Vacondio F, Morini G, Plazzi PV, Carrupt PA, Testa B. Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a  neutral heterocyclic polar group. Drug Des Discov. 2003;18(2-3):65-79. PubMed PMID: 14675944.

Kathuria S, Gaetani S, Fegley D, Valiño F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nat  Med. 2003 Jan;9(1):76-81. PubMed PMID: 12461523.