Alma universitas studiorum parmensis A.D. 962 - Università di Parma Alma universitas studiorum parmensis A.D. 962 - Università di Parma

Research lines

The activities of the Drug Design and Discovery group at the Dipartimento di Scienze degli Alimenti e del Farmaco are focused on the following research lines:

GPCR ligands

  • Design and QSAR analysis of MT1 and MT2 melatonin receptor ligands

Kinase inhibitors

  • Design and synthesis of EGFR inhibitors
  • Design and synthesis of FGFR inhibitors

Modulators of Protein-Protein Interaction

  • Design and synthesis of small molecules acting as Eph-ephrin antagonists
  • Design and synthesis of small molecules acting as FGF traps

Modulators of the Endocannabinoid System

  • Design and QSAR analysis of Fatty Acid Amide Hydrolase (FAAH) inhibitors
  • Design and QSAR of analysis N-acylethanolamine acid amidase (NAAA) inhibitors
  • Design and synthesis of Monoglyceride Lipase (MGL) inhibitors

 

Areas of general interest for the Drug Design and Discovery group are

  • Optimization of metabolic stability of drugs
  • Discovery and development of thiol-interacting drugs
  • Enzymatic reaction simulations by hybrid QM/MM approach
  • Conformational analysis of small molecules in solutions
  • Computational prediction of protein-ligand residence times

 

These research activities are managed in collaboration with other research teams of the Università di Parma:

Pharmacology Lab - Dipartimento di Scienze degli Alimenti e del Farmaco (Prof. Barocelli and Prof.Tognolini)

Experimental Oncology Lab - Dipartimento di Medicina e Chirurgia (Prof. Petronini and Prof. Alfieri)

 

or with groups belonging to other institutions:

Medicinal Chemistry Section - Dipartimento di Scienze Biomolecolari - Università degli Studi di Urbino "Carlo Bo"

Scaglione Lab - Dipartimento di Farmacologia, Chemioterapia e Tossicologia, Università degli Studi di Milano

Department of Drug Discovery & Development - Italian Institute of Technology, Genova, Italy

Piomelli Lab - Department of Pharmacology, University of California, Irvine, US

Mulholland Research Group - University of Bristol, Bristol, UK

Pasquale Lab – Sanford-Burnham Institute, La Jolla, California, US

Gobbi Lab - Neurobiological Psychiatry Unit – Dept. Psychiatry, McGill University, Montreal, Canada

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