Alma universitas studiorum parmensis A.D. 962 - Università di Parma Alma universitas studiorum parmensis A.D. 962 - Università di Parma

Research lines

The activities of the Drug Design and Discovery group are focused on the following research lines:

  • GPCR ligands
    • Design and QSAR analysis of MT1 and MT2 melatonin receptor ligands 
  • Kinase inhibitors
    • Design and synthesis of IV generation EGFR inhibitors
  • Modulators of Protein-Protein Interaction
    • Design and synthesis of small molecules acting as Eph-ephrin antagonists
    • Design and synthesis of small molecules acting as FGF traps
  • Modulators of the Endocannabinoid System
    • Design and QSAR analysis of Fatty Acid Amide Hydrolase (FAAH) inhibitors 
    • Design and QSAR of analysis N-Acylethanolamine Acid Amidase (NAAA) inhibitors
    • Design and synthesis of Monoglyceride Lipase (MGL) inhibitors

Areas of general interest for the Drug Design and Discovery group are:

  • Chemometrics applied to untargeted lipidomic data 
  • Discovery and development of thiol-interacting drugs  
  • Enzymatic reaction simulations by hybrid QM/MM approach
  • Conformational analysis of small molecules in solutions

These activities are managed in collaboration with other teams of the University of Parma:

  • Dipartimento di Medicina Clinica e Sperimentale
    • Experimental Oncology Lab - Prof. Pier Giorgio Petronini, Prof. Roberta Alfieri
  • Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale 
    • Biochemistry and Molecular Biology Lab - Prof. Barbara Montanini, 
    • Stress Physiology Lab - Prof. Andrea Sgoifo
  • Dipartimento di Scienze degli Alimenti e del Farmaco
    • Pharmacology Lab - Prof. Elisabetta Barocelli, Prof. Massimiliano Tognolini

or with research groups belonging to other institutions:

  • Department of Anatomy & Neurobiology, University of California, Irvine, US
    • Prof. Daniele Piomelli
  • Dipartimento di Medicina Molecolare e Traslazionale - Università degli Studi di Brescia
    • Prof. Marco Presta, Prof. Marco Rusnati
  • Dipartimento di Scienze Biomolecolari - Università degli Studi di Urbino
    • Prof. Gilberto Spadoni, Prof. Giorgio Tarzia 
  • School of Chemistry, University of Bristol, UK
    • Prof. Adrian Mulholland

 


 

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